AI-based staining of biological samples

The usual histological staining vs. deep learning-based digital staining. Credit score: Ozcan Lab UCLA

Histological staining, a principal device for tissue examination in clinics and life-science analysis, has been routinely carried out in pathology laboratories to help in assessing pathophysiology and illness diagnostics. Regardless of its widespread use, customary histological staining procedures are plagued with drawbacks resembling labor-intensive preparation steps, prolonged turnaround time, excessive prices, and inconsistent outcomes.

Digital staining, a deep learning-based methodology to digitally generate histological stains, has the potential to revolutionize conventional histological staining workflows. By eliminating the necessity for chemical staining and poisonous compounds, digital staining gives a fast, cost-effective, and correct different to conventional staining strategies, which might doubtlessly enhance the accuracy and pace of diagnoses, main to higher affected person outcomes and diminished healthcare prices.

The Ozcan group at UCLA has just lately revealed a Assessment paper on this rising digital staining know-how. Titled “Deep Studying-enabled Digital Histological Staining of Organic Samples,” this Assessment paper gives a complete overview of current advances within the digital staining area. It covers the fundamental ideas, the everyday growth workflow, and the long run views of deep learning-enabled digital staining know-how. It additionally highlights some key outcomes from consultant works, summarizing the up-to-date analysis progress on this quickly evolving area.

Printed in Mild: Science & Functions, a journal of the Springer Nature, this Assessment paper on digital staining gives a beneficial useful resource for students, optical engineers, microscopists, pc scientists, biologists, histologists, and pathologists alike. “We consider this Assessment paper will function an atlas of the technical developments on this analysis space, offering a top-level understanding of the most recent developments in digital staining,” mentioned Dr. Aydogan Ozcan, “and we hope it is going to encourage readers from numerous scientific fields to additional develop the scope and purposes of this thrilling area and proceed to push the boundaries of what’s potential with digital staining”.

Extra data:
Bijie Bai et al, Deep learning-enabled digital histological staining of organic samples, Mild: Science & Functions (2023). DOI: 10.1038/s41377-023-01104-7

Offered by
UCLA Engineering Institute for Expertise Development

AI-based staining of organic samples (2023, March 3)
retrieved 3 March 2023

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