Lower birth weight, more weight gain seen with in utero COVID-19 exposure

Infants with in utero publicity to COVID-19 have decrease start weight and elevated weight achieve within the first 12 months of life, in keeping with a examine printed on-line March 29 within the Journal of Scientific Endocrinology & Metabolism.

Mollie W. Ockene, from Massachusetts Normal Hospital and Harvard Medical Faculty in Boston, and colleagues carried out a longitudinal cohort examine involving 149 infants with in utero COVID-19 publicity and 127 unexposed controls. At ages 0, 2, 6, and 12 months, weight, size, and physique mass index (BMI) had been abstracted from well being data.

The researchers discovered completely different trajectories of weight and BMI, however not size, z-scores in the course of the first 12 months of life for infants with in utero COVID-19 publicity versus controls. Decrease BMI z-score at start and better achieve in BMI z-score from start to 12 months had been seen for infants born to moms with prenatal COVID-19 (impact sizes, −0.35 and 0.53, respectively). A big proportion of the connection between COVID-19 publicity and postnatal development was mediated by start weight z-score.

“The accelerated development trajectory displayed by infants with fetal publicity to COVID-19 could also be a harbinger for opposed cardiometabolic outcomes, together with weight problems and coronary heart illness, later in life,” the authors write. “Detailed physiologic research at the moment are wanted to additional delineate cardiometabolic illness danger amongst youngsters born to moms with prenatal COVID-19 as a key step towards optimizing the well being and longevity of this increasing international inhabitants.”

A number of authors disclosed monetary ties to the pharmaceutical business.

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