Uromodulin levels may indicate risk for kidney failure

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Prior research of uromodulin, probably the most plentiful protein in urine, and kidney illness have targeted totally on urinary uromodulin ranges. A examine, revealed within the American Journal of Kidney Illnesses (AJKD), evaluated associations of serum uromodulin ranges with threat of end-stage kidney illness and mortality in a cohort of African American adults with hypertension and power kidney illness.

The analysis discovered that individuals with decrease ranges of uromodulin at baseline had been extra prone to develop end-stage kidney illness, even after accounting for baseline kidney measures.

Equally, individuals who skilled steeper annual declines in uromodulin additionally had a heightened threat kidney failure. Neither baseline nor annual change in uromodulin was related to mortality. Ranges of uromodulin might be impacted by typical remedies, resembling intensive blood stress management and ramipril remedy. Serum uromodulin is a promising biomarker of kidney well being.

Extra data:
Teresa Ok. Chen et al, Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Outcomes From the African American Examine of Kidney Illness and Hypertension (AASK) Trial, American Journal of Kidney Illnesses (2023). DOI: 10.1053/j.ajkd.2023.05.017

Supplied by
Nationwide Kidney Basis

Uromodulin ranges might point out threat for kidney failure (2023, September 21)
retrieved 21 September 2023
from https://medicalxpress.com/information/2023-09-uromodulin-kidney-failure.html

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